O-succinylbenzoate synthase
function
biosynthesis of menaquinone
product
O-succinylbenzoate synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.8|Biosynthesis of menaquinone][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors], [SW|general stress proteins (controlled by SigB)], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|SigB regulon]Gene
Coordinates on the chromosome (coding sequence)
3,146,238 -> 3,147,353
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate H2O (according to Swiss-Prot)Protein family
mandelate racemase/muconate lactonizing enzyme family (according to Swiss-Prot)Structure
[PDB|1WUE] (from ''Enterococcus faecalis'', 45% identity)Expression and Regulation
Operon
''[protein|search|menF]-[protein|search|menD]-[protein|search|ytxM]-[protein|search|menB]-[protein|search|menE]-[protein|search|menC]'' [Pubmed|9387221,1629163,8550504]''[protein|search|menB]-[protein|search|menE]-[protein|search|menC]'' [Pubmed|9387221,1629163]''[protein|search|menE]-[protein|search|menC]'' [Pubmed|9387221,1629163][SW|Sigma factor]
''[protein|search|menF]'': [protein|search|SigA] [Pubmed|8550504]''[protein|search|menB]'': [protein|search|SigA] [Pubmed|9387221,1629163]''[protein|search|menE]'': [protein|search|SigA] [Pubmed|9387221,1629163]''[SW|menE]'': [SW|SigB] [Pubmed|26577401]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]References
9387221,1629163,8550504,10194342,20525796,26577401 
