multidrug ABC transporter (ATP-binding protein), also involved in the signalling pathway to activate KinA at the onset of sporulation
function
multiple antibiotic resistance
product
multidrug ABC transporter (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.1|Efflux of antibiotics][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.3|Regulatory ABC transporters][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|BmrB regulon]Gene
Coordinates on the chromosome (coding sequence)
1,047,072 -> 1,049,093
The protein
[SW|Domains]
has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453][SW|Localization]
cell membrane [Pubmed|10092453][SW|Interactions]
[protein|search|BmrC]-[protein|search|BmrD] [Pubmed|19167342]Expression and Regulation
Operon
''[protein|search|bmrB]-[protein|search|bmrC]-[protein|search|bmrD]'' [Pubmed|25217586]Regulation
induced in response to antibiotics that target protein synthesis ([protein|search|BmrB]) [Pubmed|25217586]''[protein|search|bmrB]-[protein|search|bmrC]-[protein|search|bmrD]'' expression only occurs during the late-exponential and stationary growth stages, irrespective of the timing of the antibiotic challenge ([protein|search|AbrB]) [Pubmed|25217586]Regulatory mechanism
[protein|search|AbrB]: transcription repression [Pubmed|25217586][protein|search|BmrB]: transcriptional attenuation [Pubmed|25217586]References
19167342,10092453,16487324,25217586,21602923 
