two-component sensor kinase, regulation of the dctS-dctR-dctP operon
function
regulation of the dctS-dctR-dctP operon
product
two-component sensor kinase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|protein modification], [SW|transcription factors and their control], [SW|membrane proteins], [SW|phosphoproteins]The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|search|DctR][SW|Domains]
two transmembrane segments[SW|PAS domain]C-terminal histidine phosphotransferase domainModification
autophosphorylation on a His residueEffectors of protein activity
[protein|search|DctB] and [protein|search|DctP] act as co-sensors with [protein|search|DctS] [Pubmed|24375102][SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|DctS]-[protein|search|DctR][protein|search|DctB]-[protein|search|DctS]-[protein|search|DctP], sensing complex [Pubmed|24375102]Expression and Regulation
Operon
''[protein|search|dctS]-[protein|search|dctR]-[protein|search|dctP]'' [Pubmed|10708364]Biological materials
Mutant
GP225 (''dctS''::''cat''), available in [SW|Jörg Stülke]'s labReferences
10094672,10708364,24375102