ldcB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

LD-carboxypeptidase, releases D-Ala from the cell wall

locus: BSU19620

pI: 5.84

mw: 30.00 kDa

function: cell wall synthesis

product: LD-carboxypeptidase

essential: no

synonyms: yodJ

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis]

Gene

Coordinates on the chromosome (coding sequence): 2,134,566 -> 2,135,387

The protein

Catalyzed reaction/ biological activity

• trimming of cell wall peptides (tetrapeptides to tripeptides) wit concomitant release of D-ala [Pubmed|24909784]

[SW|Cofactors]

• Zn²⁺ [Pubmed|24909784]

Structure

• [PDB|4OX3] [Pubmed|24909784]

[SW|Localization]

• extracellular (signal peptide) [Pubmed|18957862]

Expression and Regulation

Operon

• ''[protein|search|deoD]-[protein|search|ldcB]'' [Pubmed|22383849]

References

• 18957862,24909784,22383849,21378199