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liaS [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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liaS [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

two-component sensor kinase/phosphatase, response to bacitracin
Locus
BSU33090
Isoelectric point
7.00
Molecular weight
40.00 kDa
Function
control of LiaR activity in response to bacitracin
Product
two-component sensor kinase
Essential
no
Synonyms
yvqE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Protein synthesis, modification and degradation → Protein modification → Protein kinases
  • Information processing → Regulation of gene expression → Transcription factors and their control → Control of two-component response regulators → Two-component sensor kinase
  • Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
  • Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress
  • Groups of genes → Membrane proteins
  • Groups of genes → Phosphoproteins → Phosphorylation on a His residue

    • Categories containing this gene/protein

  • protein modification, transcription factors and their control, resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins

    • This gene is a member of the following regulons

  • LiaR regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,395,035 -> 3,396,117

    The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation, phosphorylation of LiaR
  • dephosphorylation of LiaR in the absence of the stress signal PubMed

    • Domains

  • two transmembrane segments, C-terminal histidine phosphotransferase domain

    • Modification

  • autophosphorylation on a His residue

    • Effectors of protein activity

  • LiaS kinase activity is inhibited by LiaF, phosphatase acitivity is maintained by LiaF in the absence of the stress signal PubMed

    • Localization

  • cell membrane (according to Swiss-Prot)

    • Interactions

  • LiaS-LiaR

    • Expression and Regulation

    Operon

  • liaI-liaH-liaG-liaF-liaS-liaR PubMed
  • liaG-liaF-liaS-liaR PubMed

    • Sigma factor

  • liaI: SigA PubMed
  • liaG: SigA PubMed

    • Regulation

  • liaI: induced by bacitracin and rhamnolipids (LiaR) PubMed
  • liaI: repressed during logarithmic growth (AbrB) PubMed, indirect regulation by AbrB PubMed
  • liaG: constitutive

    • Regulatory mechanism

  • LiaR: transcription activation PubMed

    • Labs working on this gene/protein

  • John Helmann, Cornell University, USA Homepage

    • References

    Reviews

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    Original publications

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