copper-responsive transcription repressor of the ycnK-ycnJ-ycnI operon
function
regulation of copper uptake
product
transcription repressor, DeoR family
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.1|Copper][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|YcnK regulon]Gene
Coordinates on the chromosome (coding sequence)
448,461 -> 449,033
Phenotypes of a mutant
elevated expression of ''[protein|search|ycnJ]'' under conditions of copper excess [Pubmed|19168619]The protein
Catalyzed reaction/ biological activity
repression of ''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' expression in the presence of excess copper [Pubmed|22904286,19168619]Protein family
DeoR family of transcription factors[SW|Cofactors]
copper acts as corepressor [Pubmed|19168619][SW|Interactions]
forms dimers [Pubmed|22904286]Expression and Regulation
Operon
''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' [Pubmed|22904286,22383849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|22904286]Regulation
repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|15101989]induced by copper limitation ([protein|search|YcnK]) [Pubmed|22904286]induction of the ''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' in a ''[protein|search|csoR]'' mutant results from intracellular copper depletion due to the constitutive expression of the ''[protein|search|copZ]-[protein|search|copA]'' operon (copper export) [Pubmed|22904286]Regulatory mechanism
[protein|search|AbrB]: transcription repression [Pubmed|15101989][protein|search|YcnK]: transcription repression [Pubmed|22904286]Labs working on this gene/protein
[SW|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]References
Reviews
Original publications
19168619,22904286,22383849,15101989 
