part of heam translocase, required for cytochrome c synthesis
function
cytochrome c biogenesis
product
part of the ResB-ResC haem translocase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.4|Respiration/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|respiration], [SW|essential genes], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|PhoP regulon], [SW|ResD regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane [Pubmed|19682263]Protein family
ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)[SW|Localization]
cytoplasma membrane [Pubmed|19682263][SW|Interactions]
[protein|search|ResB]-[protein|search|ResC] [Pubmed|19682263]Expression and Regulation
[SW|Sigma factor]
[protein|search|SigA] [Pubmed|8631715]Regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|9988472]repressed by glucose ([protein|search|CcpA]) [Pubmed|16825793]Regulatory mechanism
[protein|search|ResD]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed][protein|search|PhoP]: transcription activation [Pubmed|9988472][protein|search|CcpA]: transcription repression [Pubmed|16825793]References
10844653,19682263,8631715,11222591,9988472,17706591,16825793 
