oxdC

oxalate decarboxylase

Locus: BSU_33240

Isoelectric point: 5.10

Molecular weight: 43.41 kDa

Protein length: 385 aa

Gene length: 1158 bp

Function: unknown

Product: oxalate decarboxylase

Essential: no

E.C.: 4.1.1.2

Synonyms: yvrK

Genomic Context

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Categories containing this gene/protein

• Lifestyles → Coping with stress → Acid stress proteins (controlled by YvrI-YvrHa)
• Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

Gene

Coordinates: 3,410,466 3,411,623

The protein

Catalyzed reaction/ biological activity

• H⁺ + oxalate --> CO₂ + formate (according to UniProt)

Paralogous protein(s)

• OxdD

Modification

• phosphorylated on Arg-12 PubMed

Cofactors

• requires two Mn(II) centers for activity PubMed

Structure

• 1L3J PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: oxdC-rsiO
  Description: PubMed

  Sigma factors

  • SigO: sigma factor, PubMed, in SigO regulon
  • RsoA: sigma factor, in RsoA regulon

  Regulation

  • induced by acidic growth conditions PubMed

Biological materials

Mutant

• MGNA-B053 (yvrK::erm), available at the NBRP B. subtilis, Japan
• BKE33240 (oxdC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAAATGTTTCCTCCTTA, downstream forward: _UP4_TAAAAGACTTGCGGCTTGCA
• BKK33240 (oxdC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAAATGTTTCCTCCTTA, downstream forward: _UP4_TAAAAGACTTGCGGCTTGCA

Labs working on this gene/protein

• John Helmann, Cornell University, USA Homepage

References

Reviews

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Original publications

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