part of the flagellar type III export apparatus (flagellar Type III secretion system)
function
export of flagellum components
product
part of the flagellar type III export apparatus
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.2|Flagellar proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|motility and chemotaxis], [SW|protein secretion], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|DegU regulon], [SW|SigD regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
1,707,714 -> 1,709,747
Phenotypes of a mutant
no secretion of [protein|search|FlgM], permanent inhibition of [protein|search|SigD] [Pubmed|25313396]The protein
Protein family
FHIPEP (flagella/HR/invasion proteins export pore) family (according to Swiss-Prot)Structure
[PDB|3MIX] (cytosolic domain) [Pubmed|20534509][SW|Localization]
cell membrane [Pubmed|20534509], 8 transmembrane helices [Pubmed|24064315][SW|Interactions]
[protein|search|FlhA] (cytoplasmic domain) -[protein|search|FliJ] [Pubmed|20534509][protein|search|FlhA]-[protein|search|FliD] [Pubmed|20534509][protein|search|FlhA]-[protein|search|Hag] [Pubmed|20534509][protein|search|FlhA]-[protein|search|FliT] [Pubmed|20534509][protein|search|FlhA]-([protein|search|FliD]-[protein|search|FliT]) [Pubmed|20534509][protein|search|FlhA]-([protein|search|FliS]-[protein|search|Hag]) [Pubmed|20534509][protein|search|FlhA]-[protein|search|FlhB] [Pubmed|22952860]Expression and Regulation
Operon
part of the [[fla-che operon]]''[protein|search|flgB]-[protein|search|flgC]-[protein|search|fliE]-[protein|search|fliF]-[protein|search|fliG]-[protein|search|fliH]-[protein|search|fliI]-[protein|search|fliJ]-[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|9657996,8157612,15175317]''[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|20233303][SW|Sigma factor]
''[protein|search|flgB]'': [protein|search|SigA] [Pubmed|9657996], [protein|search|SigD] [Pubmed|9657996]''[protein|search|ylxF]'': [protein|search|SigD] [Pubmed|20233303]Regulation
see [[fla-che operon]]Regulatory mechanism
see [[fla-che operon]]References
Reviews
24064315,18931786,26490009 Original publications
8097015,20534509,14651647,9657996,8157612,15175317,17850253,25313396,24386445,22952860 
