fructose-specific phosphotransferase system, EIIABC of the PTS
function
fructose uptake and phosphorylation
product
fructose-specific phosphotransferase system, EIIABC
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.7|Utilization of fructose][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.3|Phosphorylation on a Cys residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|FruR regulon]The protein
Catalyzed reaction/ biological activity
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)Protein family
[SW|PTS] permease, fructose/ mannitol permease (Fru) family [Pubmed|10627040]Paralogous protein(s)
[protein|search|ManP]Structure
[PDB|2R4Q] (EIIB domain)[SW|Localization]
cell membrane (homogeneous) [Pubmed|16479537][SW|Interactions]
[protein|search|FruA]-[PtsH|search|HPr][protein|search|FruA] is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of [SW|interactions] [Pubmed|21630458]Expression and Regulation
Operon
''[protein|search|fruR]-[protein|search|fruK]-[protein|search|fruA]'' (according to [http://dbtbs.hgc.jp/COG/prom/fruRKA.html DBTBS])Regulation
induced in the presence of fructose ([protein|search|FruR]) (according to [http://dbtbs.hgc.jp/COG/prom/fruRKA.html DBTBS])Regulatory mechanism
[protein|search|FruR]: transcription repression (according to [http://dbtbs.hgc.jp/COG/prom/fruRKA.html DBTBS])References
16479537,10627040,21630458 
