two-component sensor kinase of the YvrG-YvrHb two-component system
function
regulation cell surface maintenance
product
two-component sensor histidine kinase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|transcription factors and their control], [SW|membrane proteins], [SW|phosphoproteins]Gene
Coordinates on the chromosome (coding sequence)
3,406,614 -> 3,408,356
Phenotypes of a mutant
unusual autolysis and higher susceptibility to cell envelope antibiotics (bacitracin, aztreonam, cefepime, fosfomycin) [Pubmed|16306698]The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of the [SW|YvrHb] response regulator [Pubmed|16306698]Paralogous protein(s)
[protein|search|CssS], [protein|search|YkoH], [protein|search|KinE], [protein|search|YclK][SW|Domains]
two transmembrane segments, C-terminal histidine phosphotransferase domainModification
autophosphorylation on a His residue[SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|YvrG]-[SW|YvrHb] [Pubmed|16306698]References
10094672,18820022,16306698 
