thiT [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

S protein of thiamine ECF transporter

locus: BSU30990

pI: 10.24

mw: 20.00 kDa

function: thiamine uptake

product: S protein of thiamine ECF transporter

essential: no

synonyms: yuaJ

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.3|ECF transporter]
• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.3|ECF transporter] → [category|SW 1.2.3.2|The substrate-specific S components of the ECF transporters]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|ECF transporter], [SW|biosynthesis of cofactors], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|Thi-box]

Gene

Coordinates on the chromosome (coding sequence): 3,179,306 -> 3,179,884

The protein

Protein family

• proton-coupled thiamine transporter family (according to Swiss-Prot)

Structure

• [PDB|3RLB] (from ''Lactococcus lactis'', 32% identity) [Pubmed|21706007]

[SW|Localization]

• membrane [Pubmed|18763711]

[SW|Interactions]

• [protein|search|YbaF]-[protein|search|ThiT] [Pubmed|20497229]

Expression and Regulation

Regulation

• repressed by thiamine ([protein|search|Thi-box]) [Pubmed|12376536]

Regulatory mechanism

• [protein|search|Thi-box]: [SW|RNA switch] [Pubmed|12376536]

References

Reviews

• 20497229,22574898,24362466

Original publications

• 16291685,21706007,18763711,12376536,23602660