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pabA [Tue Feb 09 2016 20:13:32 GMT+0100 (CET)]
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pabA [Tue Feb 09 2016 20:13:32 GMT+0100 (CET)]

para-aminobenzoate synthase (subunit B)/ anthranilate synthase (subunit II)
locus
BSU00750
pI
4.00
mw
21.00 kDa
function
biosynthesis of folate and tryptophan
product
para-aminobenzoate synthase (subunit B)/
anthranilate synthase (subunit II)
glutamine amidotransferase (subunit B)
and anthranilate synthase (subunit II)
essential
no
ec
2.6.1.85
synonyms
trpG, trpX
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|TRAP regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    84,290 -> 84,874

    The protein

    Catalyzed reaction/ biological activity

  • Chorismate L-glutamine = anthranilate pyruvate L-glutamate (according to Swiss-Prot)

    • Structure

  • [PDB|1I1Q] (from ''Salmonella typhimurium'', 42% identity)

    • [SW|Interactions]

  • [protein|search|PabA]-[protein|search|PabB], [protein|search|PabA]-[protein|search|TrpE]

    • Expression and Regulation

    Operon

  • ''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9084182]

    • Regulation

  • translation repressed by tryptophan ([protein|search|MtrB]) [Pubmed|9084182]

    • Regulatory mechanism

  • [protein|search|MtrB]: translation termination [Pubmed|9084182]

    • Additional information

  • the '[protein|search|pabA]-[protein|search|pabC]' part of the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]

    • References

    Reviews

  • 16285852,19385727

    • Original Publications

  • 8647825,7515880,9084182,17114263,21815947