essential for the uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2 ) into developing spores, likely germination protein
function
likely germination protein
product
binding protein for DPA
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.2|Additional germination proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|germination], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigG regulon], [SW|SpoVT regulon]Gene
Coordinates on the chromosome (coding sequence)
2,440,775 -> 2,441,791
The protein
Catalyzed reaction/ biological activity
maybe involved in spore [SW|germination] [Pubmed|22327596]binding of both DPA(2,6) and Ca(2 )-DPA(2,6) [Pubmed|22328679]Structure
[PDB|3LM6][SW|Localization]
outer surface of the inner spore membrane [Pubmed|23335419,16077113]Additional information
6,500 molecules are present per spore [Pubmed|23749970]Expression and Regulation
Operon
''[SW|spoVAA]-[SW|spoVAB]-[SW|spoVAC]-[SW|spoVAD]-[SW|spoVAEB]-[SW|spoVAEA]-[SW|spoVAF]-[protein|search|lysA]'' [Pubmed|7934830][SW|Sigma factor]
[protein|search|SigG] [Pubmed|15699190,1903432]Regulation
expressed late during sporulation in the forespore ([protein|search|SigG], [SW|SpoVT]) [Pubmed|15699190,1903432,8755877]Regulatory mechanism
[SW|SpoVT]: transcription activation [Pubmed|8755877]Additional information
6,500 molecules are present per spore [PubMed|23749970]Labs working on this gene/protein
[SW|Peter Setlow], University of Connecticut Health Center, USAReferences
17573930,3114420,16077113,11751839,15451103,3926949,17158659,6432957,22328679,7934830,15699190,1903432,8755877,22327596,22328679,22493018,23335419,23746146,22343299,23749970,24752279 
