tsf

elongation factor Ts

locus: BSU_16500

pI: 4.00

mw: 32.00 kDa

protein length: 293 aa

gene length: 882 bp

function: translation

product: elongation factor Ts

essential: yes

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]

Gene

Coordinates: 1,718,775 1,719,656

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• EF-Ts family (single member, according to UniProt)

Modification

• phosphorylation on Ser-149 [Pubmed|17218307]

Structure

• [PDB|1EFU] (the [protein|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|Tsf]-[protein|E771685D6D41D48E0C0AF77F15B4F380820FCDC2|TufA] complex from ''E. coli'', 50% identity) [Pubmed|8596629]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

additional information

• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

Expression and Regulation

Operons

• genes: [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
  description: [pubmed|22383849]

  regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [pubmed|11948165], in [regulon|stringent response|stringent response]

  regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

• 17218307,15378759,8596629,28516784