ogt [Mon Aug 31 2015 13:53:56 GMT+0200 (CEST)]

O6-methylguanine DNA alkyltransferase

locus: BSU13540

pI: 7.09

mw: 18.00 kDa

function: DNA repair

product: O6-methylguanine DNA alkyltransferase

essential: no

ec: 2.1.1.63

synonyms: dat

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

syns: dat

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

The protein

Catalyzed reaction/ biological activity

• DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine (according to Swiss-Prot)

Protein family

• MGMT family (according to Swiss-Prot)

Structure

• [PDB|1SFE] (from ''E. coli'', 36% identity, 51% similarity) [Pubmed|8156986]

Expression and Regulation

Operon

• ''[protein|search|kinE]-[protein|search|ogt]'' [Pubmed|2506524]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|2506524]

References

• 2506524,2105461,9366274