asnH [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

asparagine synthase (glutamine-hydrolysing)

locus: BSU39920

pI: 5.00

mw: 85.00 kDa

function: biosynthesis of asparagine

product: asparagine synthase (glutamine-hydrolysing))

essential: no

ec: 6.3.5.4

synonyms: yxaN

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.5|Biosynthesis/ acquisition of aspartate/ asparagine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|CodY regulon]

Gene

Coordinates on the chromosome (coding sequence): 4,098,926 -> 4,101,169

The protein

Catalyzed reaction/ biological activity

• ATP L-aspartate L-glutamine H₂O = AMP diphosphate L-asparagine L-glutamate (according to Swiss-Prot)

Protein family

• asparagine synthetase family (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|yxbB]-[protein|search|yxbA]-[protein|search|yxnB]-[protein|search|asnH]-[protein|search|yxaM]'' [Pubmed|10746760]

[SW|Sigma factor]

• [protein|search|sigA] [Pubmed|20185509]

Regulation

• repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]
• repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|15101989]

Regulatory mechanism

• [protein|search|CodY]: transcription repression [Pubmed|12618455]
• [protein|search|AbrB]: transcription repression [Pubmed|15101989]

References

Reviews

• 12859215,11395405

Original publications

• 20185509,10746760,12618455,10498721,12618455,15101989