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ylnE [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]
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ylnE [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

probable siroheme ferrochelatase
locus
BSU15620
pI
6.06
mw
28.00 kDa
function
siroheme biosynthesis, sulfite reduction
product
probable siroheme ferrochelatase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|CymR regulon], [SW|S-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,634,837 -> 1,635,622

    The protein

    Catalyzed reaction/ biological activity

  • Siroheme + 2 H+ = sirohydrochlorin + Fe2+ (according to Swiss-Prot)

    • Protein family

  • SirB subfamily (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|cysH]-[protein|search|cysP]-[protein|search|sat]-[protein|search|cysC]-[protein|search|ylnD]-[protein|search|ylnE]-[protein|search|ylnF]'' [Pubmed|11004190]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|11004190]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • repressed in the presence of cysteine ([protein|search|CymR])
  • induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]

    • Regulatory mechanism

  • [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]
  • [protein|search|CymR]: transcription repression

    • References

  • 16267287,11004190,12107147,18039762