folE2 [Sun Aug 28 2016 19:01:27 GMT+0200 (CEST)]

GTP cyclohydrolase IB, replaces FolE under conditions of zinc starvation

Locus: BSU03340

Isoelectric point: 7.00

Molecular weight: 34.00 kDa

Function: biosynthesis of folate

Product: zinc-independent GTP cyclohydrolase IB

Essential: no

E.C.: 3.5.4.16

Synonyms: yciA

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of folate
• Information processing → Protein synthesis, modification and degradation → Translation → tRNA modification and maturation

Categories containing this gene/protein

• biosynthesis of cofactors

This gene is a member of the following regulons

• Zur regulon

Gene

Coordinates on the chromosome (coding sequence): 364,259 -> 365,173

The protein

Catalyzed reaction/ biological activity

• GTP H₂O = formate 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

Protein family

• GTP cyclohydrolase IV family (according to Swiss-Prot)

Cofactors

• activated by a variety of divalent cations PubMed

Structure

• 3D1T PubMed

Interactions

• homotetrameric PubMed

Expression and Regulation

Operon

• folE2-yciB-yczL-yciC PubMed

Sigma factor

• SigA PubMed

Regulation

• induced by zinc starvation (Zur) PubMed

Regulatory mechanism

• Zur: transcription repression in the presence of zinc PubMed

References

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