SubtiBank SubtiBank
yhcA [2018-03-29 18:06:25]
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yhcA [2018-03-29 18:06:25]

similar to multidrug resistance protein
locus
BSU09010
pI
9.49
mw
58.17 kDa
protein length
532 aa Sequence Blast
gene length
1596 bp Sequence Blast
function
unknown
product
unknown
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters]
  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.3|Metabolism of signalling nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    977,775 → 979,373

    The protein

    Protein family

  • EmrB family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|188742B9A0C95344D32A4C23B9C971660572CF7D|YcnB], [protein|23483430AE0381406EF2349A18CFAE1F14F9B180|LmrB]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|EDDD61CF725449E57C72F63D378F6CD1FAC49ADA|yhbI]-[gene|211C58A92BA2A06A34B1F73BDB68A0F581B942C2|yhbJ]-[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]-[gene|7797B0B66922D51B9D142DD2E5857836E47F015B|yhcB]-[gene|95EED3A91483502CA78067421F678B1EDB965B18|yhcC]
    description
    [Pubmed|22383849]

    additional information

  • the mRNA is substantially stabilized upon depletion of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] (the half-life of the mRNA increases from 4 to 41 min) [PubMed|21815947]
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    Biological materials

    Mutant

  • MGNA-B471 (yhcA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1470 NBRP B. subtilis, Japan]
  • GP1704 (''[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]''::''ermC'', without terminator), available in [SW|Jörg Stülke]'s lab
  • BKE09010 (Δ[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE09010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTAAGACAACCTCCTTT, downstream forward: _UP4_TAATCTGTACAGGGAGGTTT
  • BKK09010 (Δ[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK09010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTAAGACAACCTCCTTT, downstream forward: _UP4_TAATCTGTACAGGGAGGTTT

    • References

  • 21815947