ylnD [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

probable uroporphyrin-III C-methyltransferase

locus: BSU15610

pI: 5.00

mw: 28.00 kDa

function: siroheme biosynthesis , sulfite reduction

product: probable uroporphyrin-III C-methyltransferase

essential: no

ec: 2.1.1.107

synonyms: sumT

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|CymR regulon], [SW|S-box]

Gene

Coordinates on the chromosome (coding sequence): 1,634,061 -> 1,634,834

The protein

Paralogous protein(s)

• [SW|NasF] (N-terminal domain)

Structure

• [PDB|1PJQ] (CysG from ''Salmonella enterica'', 46% identity) [Pubmed|14595395]

Expression and Regulation

Operon

• ''[protein|search|cysH]-[protein|search|cysP]-[protein|search|sat]-[protein|search|cysC]-[protein|search|ylnD]-[protein|search|ylnE]-[protein|search|ylnF]'' [Pubmed|11004190]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|11004190]

Regulation

• repressed by casamino acids [Pubmed|12107147]
• repressed in the presence of cysteine ([protein|search|CymR])
• induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]

Regulatory mechanism

• [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]
• [protein|search|CymR]: transcription repression

References

• 10217486,16267287,11004190,12107147,18039762,14595395