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mtnX [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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mtnX [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
locus
BSU13600
pI
4.00
mw
26.00 kDa
function
methionine salvage
product
2-hydroxy-3-keto-5-methylthiopentenyl-
1-phosphate phosphatase
essential
no
synonyms
ykrX
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|S-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,428,275 -> 1,428,982

    The protein

    Catalyzed reaction/ biological activity

  • 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one phosphate (according to Swiss-Prot)

    • Protein family

  • MtnX family (according to Swiss-Prot)
  • [SW|HAD superfamily]

    • Structure

  • [PDB|2FEA]

    • Expression and Regulation

    Operon

  • ''[protein|search|mtnW]-[protein|search|mtnX]-[protein|search|mtnB]-[protein|search|mtnD]'' [Pubmed|12022921]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|12022921]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]

    • Regulatory mechanism

  • [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]

    • References

  • 12022921,11914366,12107147,15102328,12787499,18039762,17654724