transcriptional regulator (repressor or activator) of a subset of sigma-E-dependent genes
function
regulation of mother cell gene expression
product
transcriptional regulator
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|SigE regulon]Gene
Coordinates on the chromosome (coding sequence)
3,748,421 -> 3,748,702
The protein
Catalyzed reaction/ biological activity
binds its DNA targets as a monomeric protein (possible due to the two DNA-binding motifs) [Pubmed|20061473][SW|Domains]
two DNA-binding regions: HTH at the N-terminus and a basic region near the C-terminus [Pubmed|20061473]Structure
[PDB|2L0K] (complex with DNA)Expression and Regulation
Operon
''[protein|search|usd]-[SW|spoIIID]-[protein|search|mbl]-[protein|search|flhO]-[protein|search|flhP]'' [Pubmed|9023218,7836311][SW|Sigma factor]
[protein|search|SigE] [Pubmed|9023218]Regulation
expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|9023218]References
15383836,1469717,7896717,1900494,8231808,9023218,2112673,1691789,10788508,1744038,7966271,2514119,1518043,17693505,9006059,20061473,17890309,17693499,7836311,24584501,22463703 
