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parC [2017-12-06 13:21:37]
subunit of DNA topoisomerase IV
function
chromosome segregation and compaction
product
subunit of DNA topoisomerase IV
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
1,935,448 → 1,937,868
Phenotypes of a mutant
essential [Pubmed|12682299]a ''parC'' point mutation has been isolated upon selction at low pressure [Pubmed|26296725]The protein
Protein family
topoisomerase gyrA/parC subunit family (according to Swiss-Prot)Paralogous protein(s)
[protein|B207C7328177924B16F1C606F667BEADF12CA069|GyrA]Structure
[PDB|1WP5] (C-terminal domain, Geobacillus stearothermophilus)[SW|Localization]
cytoplasm (Homogeneous) [Pubmed|16479537]polar localization in actively growing cells [Pubmed|9539793]Expression and Regulation
Operons
genes
[gene|1901C52DCB24B3D53150F6926C14907AC1B75293|parE]-[gene|9075DD0CC0B8554F0379732453665F43C70EFC26|parC]
description
[Pubmed|16267290]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [pubmed|30957856], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]regulation
induced by DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]) [Pubmed|16267290]additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''parE'' [Pubmed|27120414]view in new tabReferences
16272394,15466871,16267290,16479537,9539793,26296725