function
biosynthesis of biotin
product
cytochrome P450 enzyme
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]This gene is a member of the following [SW|regulons]
[SW|BirA regulon]Gene
Coordinates on the chromosome (coding sequence)
3,089,226 -> 3,090,413
The protein
Catalyzed reaction/ biological activity
formation of pimelic acid via a multiple-step oxidative cleavage of long-chain fatty acidsProtein family
[SW|cytochrome P450] family (according to Swiss-Prot)Structure
[PDB|3EJB], [PDB|3EJE] (complex with [protein|search|AcpA]) [Pubmed|18838690][SW|Interactions]
[protein|search|Fer]-[protein|search|BioI] [Pubmed|12538057][protein|search|YkuP]-[protein|search|BioI] [Pubmed|15449930][protein|search|AcpA]-[protein|search|BioI] [Pubmed|18838690]Expression and Regulation
Operon
''[protein|search|bioW]-[protein|search|bioA]-[protein|search|bioF]-[protein|search|bioD]-[protein|search|bioB]-[protein|search|bioI]-[protein|search|ytbQ]'' [Pubmed|8763940,8892842]Regulation
repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]Regulatory mechanism
[protein|search|BirA]: transcription repression [Pubmed|8763940,8892842]Biological materials
Mutant
MGNA-A804 (bioI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/804 NBRP B. subtilis, Japan]References
Original publications
18838690,8763940,8892842,15449931,15449930,12538057,20658980,11368323,11472016,14737344,12943422,28196402 
