bioI [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

cytochrome P450 enzyme

locus: BSU30190

pI: 6.20

mw: 44.00 kDa

function: biosynthesis of biotin

product: cytochrome P450 enzyme

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|BirA regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,089,226 -> 3,090,413

The protein

Catalyzed reaction/ biological activity

• formation of pimelic acid via a multiple-step oxidative cleavage of long-chain fatty acids

Protein family

• [SW|cytochrome P450] family (according to Swiss-Prot)

Structure

• [PDB|3EJB], [PDB|3EJE] (complex with [protein|search|AcpA]) [Pubmed|18838690]

[SW|Interactions]

• [protein|search|Fer]-[protein|search|BioI] [Pubmed|12538057]
• [protein|search|YkuP]-[protein|search|BioI] [Pubmed|15449930]
• [protein|search|AcpA]-[protein|search|BioI] [Pubmed|18838690]

Expression and Regulation

Operon

• ''[protein|search|bioW]-[protein|search|bioA]-[protein|search|bioF]-[protein|search|bioD]-[protein|search|bioB]-[protein|search|bioI]-[protein|search|ytbQ]'' [Pubmed|8763940,8892842]

Regulation

• repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]

Regulatory mechanism

• [protein|search|BirA]: transcription repression [Pubmed|8763940,8892842]

References

Reviews: [Pubmed|21437340]==

Original publications

• 18838690,8763940,8892842,15449931,15449930,12538057,20658980,11368323,11472016,14737344,12943422