ispE [Tue Dec 13 2016 11:16:29 GMT+0100 (CET)]

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, fourth step in the MEP pathway of isoprenoid biosynthesis

locus: BSU00460

pI: 6.35

mw: 31.00 kDa

function: MEP pathway of isoprenoid biosynthesis

product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

essential: yes

ec: 2.7.1.148

synonyms: yabH

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 53,516 -> 54,385

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol (according to Swiss-Prot)

Protein family

• IspE subfamily (according to Swiss-Prot)

Structure

• [PDB|1UEK] (from ''E. coli'', 38% identity) [Pubmed|12771135]

References

• 17458547,23840410,12771135