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nagA [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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nagA [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

N-acetylglucosamine-6-phosphate deacetylase
locus
BSU35010
pI
5.28
mw
42.00 kDa
function
N-acetylglucosamine utilization
product
N-acetylglucosamine-6-phosphate deacetylase
essential
no
ec
3.5.1.25
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]

    • [SW|Categories] containing this gene/protein

  • [SW|cell wall degradation/ turnover], [SW|utilization of specific carbon sources]

    • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|NagR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,595,356 -> 3,596,546

    Phenotypes of a mutant

  • no growth on N-acetylglucosamine [Pubmed|23667565]

    • The protein

    Catalyzed reaction/ biological activity

  • N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate (according to Swiss-Prot)

    • Protein family

  • nagA family (according to Swiss-Prot)

    • Kinetic information

  • K(M): 1.4 mM [Pubmed|14343123]

    • Structure

  • [PDB|2VHL] [Pubmed|14557261]

    • Expression and Regulation

    Operon

  • ''[protein|search|nagA]-[protein|search|nagB]-[protein|search|nagR]'' [Pubmed|21602348]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|23667565]

    • Regulation

  • induced in the presence of N-acetylglucosamine ([protein|search|NagR]) [Pubmed|24673833,21602348,14343123]
  • repressed by glucose (2.9-fold) ([protein|search|CcpA]) [Pubmed|12850135]

    • Regulatory mechanism

  • [protein|search|NagR]: transcription repression [Pubmed|24673833,21602348]
  • [protein|search|CcpA]: transcription repression [Pubmed|12850135]

    • References

    Reviews

  • 26159076

    • Original publications

  • 10627040,14343123,12850135,6174502,14557261,23667565,21602348,24673833,23876412,25564531