part of the condensin complex, chromosomal origin condensation and segregation
function
segregation of replication origins
product
DNA segregation and condensation protein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|stringent response]Gene
Coordinates on the chromosome (coding sequence)
2,425,831 -> 2,426,586
Phenotypes of a mutant
essential [Pubmed|12682299]''[protein|search|scpA]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]The protein
Protein family
scpA family (according to Swiss-Prot)Structure
[PDB|3ZGX] (complex between the head domain of [protein|search|Smc] (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of [protein|search|ScpA]) [Pubmed|23353789][PDB|4I98] (complex between [protein|search|ScpA] (aa 1-160)-[protein|search|ScpB] (aa 1-183) [Pubmed|23353789][SW|Localization]
nucleoid (Multiple) [Pubmed|16479537]the [SW|condensin] ([protein|search|Smc])2-[protein|search|ScpA]-[protein|search|ScpB] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [SW|Spo0J] [Pubmed|24440393,23475963][SW|Interactions]
part of the [SW|condensin] complex [Pubmed|24440399,24440393]present as stable monomer [Pubmed|22385855][protein|search|ScpA]-[protein|search|Smc] [Pubmed|23353789,22385855,12100548][protein|search|ScpA]-[protein|search|ScpB] [Pubmed|23353789,12100548]Expression and Regulation
Operon
''[protein|search|scpA]-[protein|search|scpB]-[protein|search|ypuI]'' [Pubmed|7934830]Regulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]References
Reviews
22934648,22933559,24118085,25460803,26706151 Original publications
12100548,12421306,12065423,7934830,16479537,19450516,15009890,11948165,23353789,23475963,22385855,24440399,24440393,25557547,26253537,25951515,26295962,26725510,26904953 
