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scpA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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scpA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

part of the condensin complex, chromosomal origin condensation and segregation
locus
BSU23220
pI
4.00
mw
29.00 kDa
function
segregation of replication origins
product
DNA segregation and condensation protein
essential
yes
synonyms
ypuG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|DNA condensation/ segregation], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,425,831 -> 2,426,586

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • ''[protein|search|scpA]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]

    • The protein

    Protein family

  • scpA family (according to Swiss-Prot)

    • Structure

  • [PDB|3ZGX] (complex between the head domain of [protein|search|Smc] (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of [protein|search|ScpA]) [Pubmed|23353789]
  • [PDB|4I98] (complex between [protein|search|ScpA] (aa 1-160)-[protein|search|ScpB] (aa 1-183) [Pubmed|23353789]

    • [SW|Localization]

  • nucleoid (Multiple) [Pubmed|16479537]
  • the [SW|condensin] ([protein|search|Smc])2-[protein|search|ScpA]-[protein|search|ScpB] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [SW|Spo0J] [Pubmed|24440393,23475963]

    • [SW|Interactions]

  • part of the [SW|condensin] complex [Pubmed|24440399,24440393]
  • present as stable monomer [Pubmed|22385855]
  • [protein|search|ScpA]-[protein|search|Smc] [Pubmed|23353789,22385855,12100548]
  • [protein|search|ScpA]-[protein|search|ScpB] [Pubmed|23353789,12100548]

    • Expression and Regulation

    Operon

  • ''[protein|search|scpA]-[protein|search|scpB]-[protein|search|ypuI]'' [Pubmed|7934830]

    • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

    • Biological materials

    Mutant

  • MGNA-A104 (ypuG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/104 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 22934648,22933559,24118085,25460803,26706151

    • Original publications

  • 12100548,12421306,12065423,7934830,16479537,19450516,15009890,11948165,23353789,23475963,22385855,24440399,24440393,25557547,26253537,25951515,26295962,26725510,26904953