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artP
high affinity arginine [SW|ABC transporter] (ATP-binding protein)
product
high affinity arginine [SW|ABC transporter] (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
2,492,029 2,492,796
The protein
Protein family
[SW|bacterial solute-binding protein 3 family] (according to UniProt)Structure
[PDB|4YMX] (from Caldanaerobacter subterraneus, 43% identity) [pubmed|25848002][SW|Localization]
attached to the membrane via [protein|62BD291B91DB0358754957D84A1F3636C247A697|ArtQ] [Pubmed|10092453]extracellular (signal peptide) [Pubmed|18957862], membrane [Pubmed|18763711]Expression and Regulation
Operons
genes
[gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]-[gene|62BD291B91DB0358754957D84A1F3636C247A697|artQ]-[gene|6882EF93EC82872B25C88104F62D6603D2514890|artR]
description
[Pubmed|12107147]
regulatory mechanism
[protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]regulation
repressed by casamino acids [Pubmed|12107147]induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]view in new tabBiological materials
Mutant
GP1689 Δ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]-[gene|62BD291B91DB0358754957D84A1F3636C247A697|artQ]-[gene|6882EF93EC82872B25C88104F62D6603D2514890|artR])::''mls'', available in [SW|Jörg Stülke]'s labMGNA-C381 ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2379 NBRP B. subtilis, Japan]BKE23980 ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCCATTTCCCCCGTA, downstream forward: _UP4_TAAAAAAAAGCGGCTCAACTBKK23980 ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCCATTTCCCCCGTA, downstream forward: _UP4_TAAAAAAAAGCGGCTCAACTReferences
10092453,18957862,12107147,18763711,11423008,23038252,25848002