acpA

acyl carrier protein

locus: BSU_15920

pI: 3.59

mw: 8.45 kDa

protein length: 77 aa

gene length: 234 bp

function: fatty acid biosynthesis

product: acyl carrier protein

essential: yes

synonyms: acpP

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 1,665,337 1,665,570

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• acyl carrier protein (ACP) family (single member, according to UniProt)

[SW|Domains]

• [SW|Carrier domain] (aa 2-77) (according to UniProt)

Structure

• [PDB|1F80] (complex with [protein|200BE4802FCE3C860565B374EAADC9C1FEEF3E49|AcpS]) [Pubmed|10997907], [PDB|3EJE] (complex with [protein|8FBC9A1AC108DC99E275D7A27C18C797D3CDB936|BioI]) [Pubmed|18838690], [PDB|1HY8]

[SW|Localization]

• cytoplasm (according to Swiss-Prot), during sporulation in the mother cell [Pubmed|19850612]

Expression and Regulation

Operons

• genes: [gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
  description: [Pubmed|19850612]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|16932747], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR]: repression, [Pubmed|12737802], in [regulon|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR regulon]

• genes: [gene|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]-[gene|8F5612395EBF90BEF4C80056EECAFC572384E7F8|plsX]-[gene|BB8542A6444564B21FF5DB6E2C75192C6DA2DFB8|fabD]-[gene|439B468A13137000FB42E9389391CB4986FFED84|fabG]-[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
  description: [Pubmed|19850612]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|16932747], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR]: repression, [Pubmed|12737802], in [regulon|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR regulon]
  • [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]) [Pubmed|16091051], in [regulon|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA regulon]

  regulation

  • ''[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR]'': repressed in the absence of malonyl-CoA or malonyl-[protein|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|ACP] ([protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR]) [Pubmed|12737802]
  • expression of the operon is strongly reduced during [SW|biofilm formation] [pubmed|31113899]

labs

• [SW|Diego de Mendoza], Universidad Nacional de Rosario, Argentine [http://www.ibr.gov.ar/eng/investigacion/demendoza.htm homepage]

References

Reviews

• 15952903,20658980

Original Publications

• 10997907,19850612,12737802,18838690,20201588,23033921