acpA

acyl carrier protein

Locus: BSU_15920

Isoelectric point: 3.59

Molecular weight: 8.45 kDa

Protein length: 77 aa

Gene length: 234 bp

Function: fatty acid biosynthesis

Product: acyl carrier protein

Essential: yes

Synonyms: acpP

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of fatty acids
• Groups of genes → Essential genes

Gene

Coordinates: 1,665,337 1,665,570

Phenotypes of a mutant

• essential PubMed

The protein

Protein family

• acyl carrier protein (ACP) family (single member, according to UniProt)

Domains

• Carrier domain (aa 2-77) (according to UniProt)

Structure

• 1F80 (complex with AcpS) PubMed, 3EJE (complex with BioI) PubMed, 1HY8

Localization

• cytoplasm (according to Swiss-Prot), during sporulation in the mother cell PubMed

Expression and Regulation

Operons

• Genes: acpA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • FapR: repression, PubMed, in FapR regulon

• Genes: fapR-plsX-fabD-fabG-acpA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • FapR: repression, PubMed, in FapR regulon
  • ComA: activation, (ComA) PubMed, in ComA regulon

  Regulation

  • FapR: repressed in the absence of malonyl-CoA or malonyl-ACP (FapR) PubMed
  • expression of the operon is strongly reduced during biofilm formation PubMed

Labs working on this gene/protein

• Diego de Mendoza, Universidad Nacional de Rosario, Argentine homepage

References

Reviews

Loading

Original Publications

Loading