sboA [Mon Aug 31 2015 13:57:20 GMT+0200 (CEST)]

subtilosin A

locus: BSU37350

pI: 4.57

mw: 4.00 kDa

function: antimicrobial peptide

product: subtilosin A

essential: no

synonyms: sbo

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

syns: sbo

[SW|Categories] containing this gene/protein

• [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|ResD regulon], [SW|Rok regulon]

The protein

Protein family

• bacteriocin class V family (according to Swiss-Prot)

Structure

• [PDB|1PXQ]

[SW|Localization]

• secreted (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|sboA]-[protein|search|sboX]-[protein|search|albA]-[protein|search|albB]-[protein|search|albC]-[protein|search|albD]-[protein|search|albE]-[protein|search|albF]-[protein|search|albG]'' [Pubmed|10572140]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|xxxxxx] [Pubmed|10572140]

Regulation

• repressed by [protein|search|Rok] [Pubmed|15743949]
• expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10809710]
• repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10572140,17720793 PubMed]

Regulatory mechanism

• [protein|search|Rok]: transcription repression [Pubmed|15743949]
• [protein|search|ResD]: transcription activation [Pubmed|10809710]
• [protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10572140,17720793 PubMed]

References

• 10809709,10572140,15743949,10809710,10572140,17720793