sboA

subtilosin A

Locus: BSU_37350

Isoelectric point: 4.57

Molecular weight: 4.19 kDa

Protein length: 43 aa

Gene length: 132 bp

Function: antimicrobial peptide

Product: subtilosin A

Essential: no

Synonyms: sbo

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
• Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds

Gene

Coordinates: 3,836,058 3,836,189

The protein

Protein family

• bacteriocin class V family (single member, according to UniProt)

Structure

• 1PXQ

Localization

• secreted (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: sboA-sboX-albA-albB-albC-albD-albE-albF-albG
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • Rok: repression, PubMed, in Rok regulon
  • ResD: activation, PubMed, in ResD regulon
  • AbrB: repression, PubMed, in AbrB regulon

  Regulation

  • expressed under anaerobic conditions (ResD) PubMed
  • expression of the operon is strongly induced at the beginning of biofilm formation PubMed

Biological materials

Mutant

• BKE37350 (sboA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAATTGAATCCTCCCTTT, downstream forward: _UP4_CTAGTGGACGGTCCTATCCC
• BKK37350 (sboA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAATTGAATCCTCCCTTT, downstream forward: _UP4_CTAGTGGACGGTCCTATCCC

References

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