alaS

alanine-tRNA synthetase

Locus: BSU_27410

Isoelectric point: 4.92

Molecular weight: 97.08 kDa

Protein length: 878 aa

Gene length: 2637 bp

Function: translation

Product: alanine-tRNA synthetase

Essential: yes

E.C.: 6.1.1.7

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Translation → Aminoacyl-tRNA synthetases
• Groups of genes → Essential genes

Gene

Coordinates: 2,798,174 2,800,810

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-alanine + tRNA^Ala --> AMP + diphosphate + L-alanyl-tRNA^Ala (according to UniProt)

Protein family

• Class-II aminoacyl-tRNA synthetase family (according to UniProt)

Structure

• 1YFS (enzyme from Aquifex aeolicus) PubMed
• 3HXU (enzyme from E. coli with alanine) PubMed

Expression and Regulation

Operons

• Genes: alaS-reoM-yrrK-yrzB
  Description: PubMed

  Regulatory mechanism

  • T-box: antitermination, in T-box

  Regulation

  • induced by alanine limitation (T-box) PubMed

References

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