pucH [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

allantoinase

locus: BSU32410

pI: 5.06

mw: 48.00 kDa

function: purine utilization

product: allantoinase

essential: no

ec: 3.5.2.5

synonyms: yunH

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.1|Utilization of nucleotides]

[SW|Categories] containing this gene/protein

• [SW|utilization of nucleotides], [SW|sporulation proteins]

This gene is a member of the following [SW|regulons]

• [SW|PucR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,327,247 -> 3,328,587

The protein

Catalyzed reaction/ biological activity

• (S)-allantoin + H₂O = allantoate (according to Swiss-Prot)

Protein family

• Allantoinase subfamily (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|PyrC]

Structure

• [PDB|3HM7] (from ''Bacillus halodurans'', 44% identity, 65% similarity)

Expression and Regulation

Operon

• ''pucH'' [Pubmed|12029039]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|12029039]

Regulation

• induced in the presence of purine nucleotides (inducer: allantoin) ([protein|search|PucR]) [Pubmed|12029039]

Regulatory mechanism

• [protein|search|PucR]: transcription activation [Pubmed|12029039]

References

• 11344136,12029039