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tapA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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tapA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

TasA anchoring/assembly protein
locus
BSU24640
pI
6.00
mw
28.00 kDa
function
biofilm formation
product
TasA anchoring/assembly protein
essential
no
synonyms
yqhD, yqxM
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.2|Amyloid protein synthesis, secretion and assembly]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|biofilm formation], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|RemA regulon], [SW|SinR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,554,486 -> 2,555,247

    Phenotypes of a mutant

  • no biofilm formation [Pubmed|24488317]

    • The protein

    [SW|Localization]

  • attached to the cell surface (on the outside of the cell), associated with peptidoglycan [Pubmed|21477127]
  • secretion requires [protein|search|SipW] [Pubmed|10559173]

    • [SW|Interactions]

  • [protein|search|TapA]-[protein|search|TasA] [Pubmed|24488317]
  • [protein|search|SipW]-[protein|search|TapA] [Pubmed|10559173]

    • Expression and Regulation

    Operon

  • ''[protein|search|tapA]-[protein|search|sipW]-[protein|search|tasA]'' [Pubmed|16430695]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|16430695]

    • Regulation

  • repressed by [protein|search|SinR] [Pubmed|16430695]
  • repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]

    • Regulatory mechanism

  • [protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]
  • [protein|search|SinR]: transcription repression [Pubmed|16430695]
  • [protein|search|RemA]: transcription activation [Pubmed|23646920]
  • [protein|search|LutR]: transcription activation [Pubmed|24196425]

    • Additional information

  • induction by sequestration of [protein|search|SinR] by [protein|search|SinI] or [protein|search|SlrA] [PubMed|15661000,19788541] or by SlrR [PubMed|20351052]
  • the '[protein|search|tapA]-[protein|search|sipW]-[protein|search|tasA]' operon is not expressed in a '[protein|search|ymdB]' mutant [PubMed|21856853]
  • the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] (this is likely due to the increased stability of the '[protein|search|sinR]' mRNA) [PubMed|21815947]

    • Biological materials

    lacZ fusion

  • pGP1926 (in [protein|search|pAC6]), available in [SW|Stülke] lab

    • References

    Reviews

  • 21488983,25907113

    • Original publications

  • 18430133,18047568,18647168,20351052,16430695,10464223,17720793,19605685,20431016,10559173,21477127,21856853,21815947,23646920,24488317,25894589,26819068