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rapE
response regulator aspartate phosphatase, dephosphorylates Spo0F-P, control of the phosphorelay
function
control of sporulation initiation
product
response regulator aspartate phosphatase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.2|Response regulator aspartate phosphatase][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.5|Phosphatases controlling the phosphorelay][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.5|Phosphatases controlling the phosphorelay][category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.3|Skin element]Gene
Coordinates
2,659,213 2,660,340
The protein
Protein family
[SW|RAP family] (according to UniProt)[SW|Domains]
six [SW|TPR repeat|tetratrichopeptide repeats] (according to UniProt)Structure
[PDB|4I9E] ([protein|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|RapF], 38% identity) [pubmed|23526880]Expression and Regulation
Operons
genes
[gene|8B8646DF7F437D8DB299A77BA937DC6FC082102F|rapE]-[gene|997434F9679B3A2F8D2453D0C3BAB24F5BB90922|phrE]
description
[Pubmed|11466295,10629174]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|23569278,12618455], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon][protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]: activation, in [regulon|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA regulon]regulation
repressed by glucose (10-fold) ([protein|search|CcpA]) [Pubmed|12850135]view in new tabBiological materials
Mutant
BKE25830 ([gene|8B8646DF7F437D8DB299A77BA937DC6FC082102F|rapE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGATATTCACCCTTCCCT, downstream forward: _UP4_CAAATATCGAAAGGGGAATGBKK25830 ([gene|8B8646DF7F437D8DB299A77BA937DC6FC082102F|rapE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGATATTCACCCTTCCCT, downstream forward: _UP4_CAAATATCGAAAGGGGAATGReferences
12618455,11466295,10629174,23569278,25225273,23526880