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bioF [Mon Aug 31 2015 13:56:21 GMT+0200 (CEST)]
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bioF [Mon Aug 31 2015 13:56:21 GMT+0200 (CEST)]

8-amino-7-oxononanoate synthase
locus
BSU30220
pI
6.29
mw
42.00 kDa
function
biosynthesis of biotin
product
8-amino-7-oxononanoate synthase
essential
no
ec
2.3.1.47
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|BirA regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2 (according to Swiss-Prot)

    • Protein family

  • class-II pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|bioW]-[protein|search|bioA]-[protein|search|bioF]-[protein|search|bioD]-[protein|search|bioB]-[protein|search|bioI]-[protein|search|ytbQ]'' [Pubmed|8763940,8892842]

    • Regulation

  • repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]

    • Regulatory mechanism

  • [protein|search|BirA]: transcription repression [Pubmed|8763940,8892842]

    • References

    Reviews
    [Pubmed|21437340]==

    Original publications

  • 8763940,8892842,21821766,22960854