yfmH

leader peptide to control amino acid-regulated [gene|893BB8D1B43F10B46BB7F2DBFE9BE63E9AEEE8EB|yfmG] expression

locus: new_820648_820823

pI: 0.00

mw: 0.00 kDa

gene length: 176 bp

function: control of amino acid-regulated [gene|893BB8D1B43F10B46BB7F2DBFE9BE63E9AEEE8EB|yfmG] expression

product: leader peptide

synonyms: S254

Genomic Context

Gene

Coordinates: 820,648 → 820,823

The protein

Catalyzed reaction/ biological activity

• leader peptide [pubmed|32611709]

Expression and Regulation

Operons

• genes: [gene|8A9E5A121CA2C5CE8A7A2DD2FDCE2AD5FCB356BF|yfmH]-[gene|893BB8D1B43F10B46BB7F2DBFE9BE63E9AEEE8EB|yfmG]
  description: [Pubmed|32611709]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [pubmed|32611709], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|20817675], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
  • [protein|8A9E5A121CA2C5CE8A7A2DD2FDCE2AD5FCB356BF|YfmH]: attenuation, [pubmed|32611709], in [regulon|8A9E5A121CA2C5CE8A7A2DD2FDCE2AD5FCB356BF|YfmH regulon]

  regulation

  • repressed by glucose (4-fold) [Pubmed|12850135]

  additional information

  • A [protein|search|ncRNA] is predicted between [gene|3DFC1A118B346C7939851BF711FFA31E04A698E8|yfmI] and [gene|893BB8D1B43F10B46BB7F2DBFE9BE63E9AEEE8EB|yfmG], this has been shown to encode the leader peptide, [protein|8A9E5A121CA2C5CE8A7A2DD2FDCE2AD5FCB356BF|YfmH] [PubMed|32611709,20525796]
  • Expression of [gene|893BB8D1B43F10B46BB7F2DBFE9BE63E9AEEE8EB|yfmG] is controlled by [protein|8A9E5A121CA2C5CE8A7A2DD2FDCE2AD5FCB356BF|YfmH]-mediated attenuation: slow translation rates of [protein|8A9E5A121CA2C5CE8A7A2DD2FDCE2AD5FCB356BF|YfmH] due to amino acid limitation prevent the formation in the [gene|893BB8D1B43F10B46BB7F2DBFE9BE63E9AEEE8EB|yfmG] leader (reduced expression of [gene|893BB8D1B43F10B46BB7F2DBFE9BE63E9AEEE8EB|yfmG] if amino acids are available in excess) [pubmed|32611709]

References

Research papers

• 32611709