fadR [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

transcriptional repressor (TetR family), regulation of fatty acid degradation

Locus: BSU28550

Isoelectric point: 6.12

Molecular weight: 21.00 kDa

Function: regulation of fatty acid degradation

Product: transcriptional repressor

Essential: no

Synonyms: ysiA

Genomic Context

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Categories containing this gene/protein

• Metabolism → Lipid metabolism → Utilization of lipids → Utilization of fatty acids
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

Categories containing this gene/protein

• utilization of lipids, transcription factors and their control

This gene is a member of the following regulons

• CcpA regulon, FadR regulon

Gene

Coordinates on the chromosome (coding sequence): 2,917,957 -> 2,918,541

The protein

Protein family

• TetR family

Effectors of protein activity

• long chain fatty acids act as inducers that release FadR from its operator sites PubMed

Expression and Regulation

Operon

• lcfA-fadR-fadB-etfB-etfA PubMed
• fadR-fadB-etfB-etfA PubMed

Sigma factor

• lcfA: SigA PubMed
• fadR: SigA PubMed

Regulation

• induced by long-chain fatty acids (FadR) PubMed
• subject to carbon catabolite repression (CcpA-[PtsH|search|HPr(Ser-P)] PubMed

Regulatory mechanism

• FadR: transcription repression PubMed
• CcpA-[PtsH|search|HPr(Ser-P)]: transcription repression PubMed

Biological materials

Mutant

• 1A853 ( fadR::cat), PubMed, available at BGSC

References

Reviews

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Original publications

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