transcriptional repressor (TetR family), regulation of fatty acid degradation
function
regulation of fatty acid degradation
product
transcriptional repressor
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|utilization of lipids], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|FadR regulon]Gene
Coordinates on the chromosome (coding sequence)
2,917,957 -> 2,918,541
The protein
Protein family
[SW|TetR family]Effectors of protein activity
long chain fatty acids act as inducers that release FadR from its operator sites [Pubmed|24356978]Expression and Regulation
Operon
''[protein|search|lcfA]-[protein|search|fadR]-[protein|search|fadB]-[protein|search|etfB]-[protein|search|etfA]'' [Pubmed|17189250]''[protein|search|fadR]-[protein|search|fadB]-[protein|search|etfB]-[protein|search|etfA]'' [Pubmed|17189250][SW|Sigma factor]
''[protein|search|lcfA]'': [protein|search|SigA] [Pubmed|21398533]''[protein|search|fadR]'': [protein|search|SigA] [Pubmed|17189250]Regulation
induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]subject to carbon catabolite repression ([protein|search|CcpA]-[PtsH|search|HPr(Ser-P)] [Pubmed|21398533]Regulatory mechanism
[protein|search|FadR]: transcription repression [Pubmed|17189250][protein|search|CcpA]-[PtsH|search|HPr(Ser-P)]: transcription repression [Pubmed|21398533]Biological materials
Mutant
1A853 ( ''fadR''::''cat''), [Pubmed|17085570], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A853&Search=1A853 BGSC]References
Reviews
Original publications
17189250,21398533,24356978 
