SubtiBank SubtiBank
yqgP
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yqgP

intramembrane protease
Locus
BSU_24870
Isoelectric point
5.51
Molecular weight
56.27 kDa
Protein length
507 aa Sequence Blast
Gene length
1524 bp Sequence Blast
Function
cell division
Product
intramembrane protease
Essential
no
Synonyms
glpG,gluP

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,571,907 2,573,430

Phenotypes of a mutant

  • filamentous phenotype PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains (according to UniProt)
  • cleavage of MgtE between its first and second trans-membrane helix at low magnesium concentration or high manganese or zinc concentrations to prevent uptake of toxic metal ions PubMed
  • acts as adapter protein for FtsH PubMed
  • Protein family

  • peptidase S54 family (according to UniProt)
  • Paralogous protein(s)

    Domains

  • two tetratrichopeptide repeats (according to UniProt)
  • Effectors of protein activity

  • Mn2+ and Zn2+ bind to the N-terminal cytosolic domain of YqgE to stimulate MgtE degradation PubMed
  • Localization

  • cell membrane PubMed
  • Expression and Regulation

    Operons

    Description

    Additional information

  • PhoP∼P binds to the promoter region, but regulation has not been explored PubMed
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    Biological materials

    Mutant

  • MGNA-C445 (yqgP::erm), available at the NBRP B. subtilis, Japan
  • BKE24870 (yqgP::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTTACCGCTCCAATAG, downstream forward: _UP4_TAGAGGTGGAATATGGAAAG
  • BKK24870 (yqgP::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTTACCGCTCCAATAG, downstream forward: _UP4_TAGAGGTGGAATATGGAAAG
  • References

    Reviews

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    Original publications

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