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yqgP
Molecular weight
56.27 kDa
Product
intramembrane protease
Genomic Context
Categories containing this gene/protein
Gene
Coordinates
2,571,907 2,573,430
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains (according to UniProt)cleavage of MgtE between its first and second trans-membrane helix at low magnesium concentration or high manganese or zinc concentrations to prevent uptake of toxic metal ions PubMedacts as adapter protein for FtsH PubMed Protein family
Paralogous protein(s)
Domains
Effectors of protein activity
Mn2+ and Zn2+ bind to the N-terminal cytosolic domain of YqgE to stimulate MgtE degradation PubMed Localization
Expression and Regulation
Biological materials
Mutant
MGNA-C445 (yqgP::erm), available at the NBRP B. subtilis, JapanBKE24870 (yqgP::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTTACCGCTCCAATAG, downstream forward: _UP4_TAGAGGTGGAATATGGAAAGBKK24870 (yqgP::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTTACCGCTCCAATAG, downstream forward: _UP4_TAGAGGTGGAATATGGAAAG References
Reviews
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Original publications
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