inhibitor of AbrB activity
function
inhibition of AbrB
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)][SW|Categories] containing this gene/protein
[SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
1,485,118 -> 1,485,315
The protein
Catalyzed reaction/ biological activity
inhibition of AbrB activity [Pubmed|18840696]Structure
[http://pdb.org/pdb/explore/explore.do?structureId=2LZF 2LZF] [Pubmed|24534728][SW|Interactions]
forms dimers [Pubmed|24534728][protein|search|AbbA]-[protein|search|AbrB], [protein|search|AbbA] binds the N-terminal DNA-binding domain of [protein|search|AbrB] [Pubmed|24534728,18840696]Expression and Regulation
Operon
''[protein|search|ykuJ]-[protein|search|ykuK]-[protein|search|abbA]-[protein|search|ykuL]-[protein|search|ccpC]'' [Pubmed|16395550]Regulation
repressed by glucose (4.3-fold) ([protein|search|CcpA]) [Pubmed|12850135]expressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|18840696,14651647]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|12850135][SW|Spo0A]: transcription activation by [SW|Spo0A]~P [Pubmed|18840696,14651647]Biological materials
Mutant
GP214 (deletion of ''[protein|search|ykuJ]-[protein|search|ykuK]-[protein|search|abbA]-[protein|search|ykuL]'', replaced by ''aphA3''), available in the [SW|Stülke] lablacZ fusion
pGP708 (in [protein|search|pAC5]), available in [SW|Stülke] lab, pGP712 (in [protein|search|pAC6]), available in [SW|Stülke] labLabs working on this gene/protein
[SW|Richard Losick], Harvard Univ., Cambridge, USA [http://www.mcb.harvard.edu/Losick/ homepage]References
24534728,18840696,14651647,12850135,18840696,12850135,16395550 
