codV [Fri Jan 29 2016 15:43:12 GMT+0100 (CET)]

site-specific integrase/recombinase, partitioning of the terminus region after replication

locus: BSU16140

pI: 9.00

mw: 35.00 kDa

function: chromosome partitioning

product: site-specific integrase/recombinase

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]

[SW|Categories] containing this gene/protein

• [SW|DNA condensation/ segregation]

This gene is a member of the following [SW|regulons]

• [SW|CodY regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,687,187 -> 1,688,101

The protein

Catalyzed reaction/ biological activity

• resolution of chromosome dimers by site specific recombination at the dif site (located close to the terminus region on the chromosome)

Protein family

• XerC subfamily (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|RipX]

Structure

• [PDB|1A0P] (from ''E. coli'', 39% identity, complex with [SW|RipX])

[SW|Localization]

• cytoplasm (according to Swiss-Prot)
• assembles on the chromosome at the dif site throughout the cell cycle [Pubmed|21239579]

Expression and Regulation

Operon

• ''[protein|search|codV]-[protein|search|clpQ]-[protein|search|clpY]-[protein|search|codY]'' [Pubmed|7783641]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|7783641]

Regulation

• repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|11331605]

Regulatory mechanism

• [protein|search|CodY]: transcription repression [Pubmed|11331605]

Biological materials

Mutant

• 1A794 ( ''codV''::''kan''), [Pubmed|10498718], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A794&Search=1A794 BGSC]

References

Reviews

• 23400100

Original publications

• 10498718,16597952,11208805,11331605,7783641,21239579