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hisB [Tue Oct 25 2016 16:58:37 GMT+0200 (CEST)]
imidazoleglycerol-phosphate dehydratase
function
biosynthesis of histidine
product
imidazoleglycerol-phosphate dehydratase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]Gene
Coordinates on the chromosome (coding sequence)
3,585,690 -> 3,586,274
The protein
Catalyzed reaction/ biological activity
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate H2O (according to Swiss-Prot) Protein family
imidazoleglycerol-phosphate dehydratase family (according to Swiss-Prot)Structure
[PDB|2AE8] (from ''Staphylococcus aureus subsp. aureus n315 mutant'', 48% identity, 65% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|hisZ]-[protein|search|hisG]-[protein|search|hisD]-[protein|search|hisB]-[protein|search|hisH]-[protein|search|hisA]-[protein|search|hisF]-[protein|search|hisI]'' [Pubmed|12107147]Regulation
repressed by casamino acids [Pubmed|12107147]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
