cysteine desulfurase, cysteine:SufU sulfuryl transferase
function
formation of iron-sulfur clusters in proteins
product
cysteine desulfurase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.3|Biosynthesis of iron-sulfur clusters][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|iron metabolism], [SW|essential genes]Gene
Coordinates on the chromosome (coding sequence)
3,357,444 -> 3,358,664
Phenotypes of a mutant
essential [Pubmed|12682299]terminal phenotype of a CRISPRi knockdown mutant is moderate bulging [Pubmed|27238023]The protein
Catalyzed reaction/ biological activity
transfer of iron to [protein|search|SufU] [Pubmed|21236255]Protein family
Csd subfamily (according to Swiss-Prot)Paralogous protein(s)
[protein|search|NifS], [protein|search|YrvO], [protein|search|NifZ], [protein|search|YcbU][SW|Cofactors]
pyridoxalphosphate [Pubmed|25447671]Effectors of protein activity
interaction with [protein|search|SufU] enhances the activity of [protein|search|SufS] 40-fold [Pubmed|20097860]Structure
[PDB|5J8Q] [Pubmed|27382962][SW|Interactions]
[SW|SufS]-[SW|SufS], forms homodimers [Pubmed|27382962][protein|search|SufS]-[protein|search|SufU] [Pubmed|20097860,21236255][SW|Fra]-[SW|SufS] [Pubmed|27382962]Expression and Regulation
Operon
''[protein|search|sufC]-[protein|search|sufD]-[protein|search|sufS]-[protein|search|sufU]-[protein|search|sufB]'' [Pubmed|22383849]Biological materials
Mutant
BEC32690, a CRISPRi knockdown mutant of ''[protein|search|sufU]'', is available from the [http://bgsc.org/ Bacillus Genetic Stock Center]References
Reviews
Original publications
21236255,20097860,20822158,22383849,24321018,15379559,27382962,27238023 
