modulation of CheA activity in response to attractants, scaffold protein: facilitates coupling between CheA and receptors
function
control of CheA activity
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.2|Coupling proteins][SW|Categories] containing this gene/protein
[SW|motility and chemotaxis]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|DegU regulon], [SW|SigD regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
1,714,855 -> 1,715,325
Phenotypes of a mutant
''[protein|search|cheV] [protein|search|cheW]'' double mutants exhibit complete loss of chemotaxis [Pubmed|21098025]The protein
Paralogous protein(s)
[protein|search|CheV] (N-terminal domain)[SW|Localization]
cytoplasm (according to Swiss-Prot)predominantly present at the cell poles [Pubmed|21098025][SW|Interactions]
[protein|search|CheA]-[protein|search|CheW] [Pubmed|25039821][protein|search|McpB]-[protein|search|CheW] [Pubmed|25039821]Additional information
:subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed] Expression and Regulation
Operon
part of the [[fla-che operon]]''[protein|search|flgB]-[protein|search|flgC]-[protein|search|fliE]-[protein|search|fliF]-[protein|search|fliG]-[protein|search|fliH]-[protein|search|fliI]-[protein|search|fliJ]-[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|9657996,8157612,15175317]''[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|20233303][SW|Sigma factor]
''[protein|search|flgB]'': [protein|search|SigA] [Pubmed|9657996], [protein|search|SigD] [Pubmed|9657996]''[protein|search|ylxF]'': [protein|search|SigD] [Pubmed|20233303]Regulation
see [[fla-che operon]]Regulatory mechanism
see [[fla-che operon]]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]in minimal medium, CheW is present with 2,100 /- 430 molecules per cell [PubMed|21515776] References
Reviews
Original publications
8169224,1601874,14731274,1624415,14651647,9657996,8157612,15175317,17850253,21098025,21515776,24386445,25039821 
