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cheW [Mon May 16 2016 17:11:38 GMT+0200 (CEST)]
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cheW [Mon May 16 2016 17:11:38 GMT+0200 (CEST)]

modulation of CheA activity in response to attractants, scaffold protein: facilitates coupling between CheA and receptors
Locus
BSU16440
Isoelectric point
4.00
Molecular weight
17.00 kDa
Function
control of CheA activity
Product
CheA modulator
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Lifestyles → Exponential and early post-exponential lifestyles → Motility and chemotaxis → Signal transduction in motility and chemotaxis → Coupling proteins

    • Categories containing this gene/protein

  • motility and chemotaxis

    • This gene is a member of the following regulons

  • CodY regulon, DegU regulon, SigD regulon, Spo0A regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,714,855 -> 1,715,325

    Phenotypes of a mutant

  • cheV cheW double mutants exhibit complete loss of chemotaxis PubMed

    • The protein

    Paralogous protein(s)

  • CheV (N-terminal domain)

    • Localization

  • cytoplasm (according to Swiss-Prot)
  • predominantly present at the cell poles PubMed

    • Interactions

  • CheA-CheW PubMed
  • McpB-CheW PubMed

    • Additional information

  • :
  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]

    • Expression and Regulation

    Operon

  • part of the [[fla-che operon]]
  • flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB PubMed
  • ylxF-fliK-flgD-flgE-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB PubMed

    • Sigma factor

  • flgB: SigA PubMed, SigD PubMed
  • ylxF: SigD PubMed

    • Regulation

  • see [[fla-che operon]]

    • Regulatory mechanism

  • see [[fla-che operon]]

    • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]
  • in minimal medium, CheW is present with 2,100 /- 430 molecules per cell PubMed

    • References

    Reviews

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    Original publications

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