ytpQ [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

unknown

locus: BSU29830

pI: 5.30

mw: 30.00 kDa

function: maybe involved in iron homeostasis

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

[SW|Categories] containing this gene/protein

• [SW|acquisition of iron], [SW|resistance against oxidative and electrophile stress]

This gene is a member of the following [SW|regulons]

• [SW|Spx regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,053,364 -> 3,054,173

Phenotypes of a mutant

• derepression of the [protein|search|Fur] and [protein|search|PerR] regulons [Pubmed|21949854]
• elevated oxidative protein damage upon exposure of the cells to methylglyoxal [Pubmed|21949854]
• the ''[protein|search|spx] [protein|search|ytpQ]'' doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal [Pubmed|21949854]

The protein

Protein family

• UPF0354 family (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|ytpP]-[protein|search|ytpQ]-[protein|search|ytpR]'' [Pubmed|21949854]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|21949854]

Regulatory mechanism

• [protein|search|Spx]: transcription activation [Pubmed|21949854]

References

• 21949854