ytpQ

unknown

Locus: BSU_29830

Isoelectric point: 5.30

Molecular weight: 30.89 kDa

Protein length: 269 aa

Gene length: 810 bp

Function: maybe involved in iron homeostasis

Product: unknown

Essential: no

Synonyms

Genomic Context

Loading

Categories containing this gene/protein

• Cellular processes → Homeostasis → Acquisition of iron → Acquisition of iron / Other
• Metabolism → Additional metabolic pathways → Iron metabolism → Acquisition of iron / Other
• Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress

Gene

Coordinates: 3,053,364 3,054,173

Phenotypes of a mutant

• derepression of the Fur and PerR regulons PubMed
• elevated oxidative protein damage upon exposure of the cells to methylglyoxal PubMed
• the spx ytpQ doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal PubMed

The protein

Protein family

• UPF0354 family (single member, according to UniProt)

Expression and Regulation

Operons

• Genes: ytpP-ytpQ-ytpR
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • Spx: activation, PubMed, in Spx regulon

Biological materials

Mutant

• MGNA-A437 (ytpQ::erm), available at the NBRP B. subtilis, Japan
• BKE29830 (ytpQ::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTTCAAACCGATGTCCT, downstream forward: _UP4_AAGGATTAGAAAGGATTTTT
• BKK29830 (ytpQ::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTTCAAACCGATGTCCT, downstream forward: _UP4_AAGGATTAGAAAGGATTTTT

References

Loading