long chain-fatty acid beta-hydroxylating cytochrome P450, H(2)O(2)-dependent, hydroxylates myristic acid to beta-hydroxymyristic acid, required for protection against paraquat stress
function
biosynthesis of beta-hydroxy fatty acid for lipopeptides
product
fatty acid beta-hydroxylating cytochrome P450, protection against paraquat stress
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.3|Lipid metabolism/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][SW|Categories] containing this gene/protein
[SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress], [SW|electron transport/ other], [SW|lipid metabolism/ other]This gene is a member of the following [SW|regulons]
[SW|SigB regulon]Gene
Coordinates on the chromosome (coding sequence)
229,525 -> 230,778
The protein
Catalyzed reaction/ biological activity
hydroxylation of a long-chain fatty acid (e.g. myristic acid) at the alpha- and beta-positions using hydrogen peroxide as an oxidant [Pubmed|12519760]Protein family
[SW|cytochrome P450] family (according to Swiss-Prot)Structure
[PDB|2ZQJ] [PDB|1IZO][Pubmed|12519760]Expression and Regulation
Operon
''cypC'' (according to [http://dbtbs.hgc.jp/COG/prom/cypC.html DBTBS])[SW|Sigma factor]
[protein|search|SigB] [Pubmed|15805528]Regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]References
12297285,11827534,11566026,17385817,11914497,10529095,12519760,15805528,23586998,20697922,21673922,22582280 
